USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: Q14203 USC-OGP 2-DE database:  Q14203 Q14203 General information about the entry View entry in simple text format Entry name DCTN1_HUMAN Primary accession number Q14203 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Dynactin subunit 1; AltName: Full=150 kDa dynein-associated polypeptide; AltName: Full=DAP-150; Short=DP-150; AltName: Full=p135; AltName: Full=p150-glued;. Gene name Name=DCTN1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0073: pI=4.76; Mw=50391 SPOT OGP-0212: pI=4.61; Mw=22361 SPOT OGP-0215: pI=4.66; Mw=21383 Cross-references UniProtKB/Swiss-Prot Q14203; DCTN1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name DCTN1_HUMAN Primary accession number Q14203 Secondary accession number(s) A8MY36 B4DM45 E9PFS5 E9PGE1 G5E9H4 O95296 Q6IQ37 Q9BRM9 Q9UIU1 Q9UIU2 Sequence was last modified on  October 18, 2001 (version 3) Annotations were last modified on  March 15, 2017 (version 174) Name and origin of the protein Description RecName: Full=Dynactin subunit 1; AltName: Full=150 kDa dynein-associated polypeptide; AltName: Full=DAP-150; Short=DP-150; AltName: Full=p135; AltName: Full=p150-glued; Gene name Name=DCTN1 Encoded on Name=DCTN1 Keywords 3D-structure; Alternative splicing; Amyotrophic lateral sclerosis; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Neurodegeneration; Nucleus; Parkinsonism; Phosphoprotein; Polymorphism; Reference proteome; Transport; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF064205; AAD55811.1; -; Genomic_DNA EMBL AF064203; AAD55811.1; JOINED; Genomic_DNA EMBL AF064204; AAD55811.1; JOINED; Genomic_DNA EMBL AF064205; AAD55812.1; -; Genomic_DNA EMBL AF064204; AAD55812.1; JOINED; Genomic_DNA EMBL AK297286; BAG59757.1; -; mRNA EMBL AK314352; -; NOT_ANNOTATED_CDS; mRNA EMBL AC005041; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471053; EAW99684.1; -; Genomic_DNA EMBL BC071583; AAH71583.1; -; mRNA EMBL X98801; CAA67333.1; -; mRNA EMBL AF086947; AAD03694.1; -; Genomic_DNA EMBL AF086927; AAD03694.1; JOINED; Genomic_DNA EMBL AF086928; AAD03694.1; JOINED; Genomic_DNA EMBL AF086929; AAD03694.1; JOINED; Genomic_DNA EMBL AF086930; AAD03694.1; JOINED; Genomic_DNA EMBL AF086931; AAD03694.1; JOINED; Genomic_DNA EMBL AF086932; AAD03694.1; JOINED; Genomic_DNA EMBL AF086933; AAD03694.1; JOINED; Genomic_DNA EMBL AF086934; AAD03694.1; JOINED; Genomic_DNA EMBL AF086935; AAD03694.1; JOINED; Genomic_DNA EMBL AF086936; AAD03694.1; JOINED; Genomic_DNA EMBL AF086937; AAD03694.1; JOINED; Genomic_DNA EMBL AF086938; AAD03694.1; JOINED; Genomic_DNA EMBL AF086939; AAD03694.1; JOINED; Genomic_DNA EMBL AF086940; AAD03694.1; JOINED; Genomic_DNA EMBL AF086941; AAD03694.1; JOINED; Genomic_DNA EMBL AF086942; AAD03694.1; JOINED; Genomic_DNA EMBL AF086943; AAD03694.1; JOINED; Genomic_DNA EMBL AF086944; AAD03694.1; JOINED; Genomic_DNA EMBL AF086945; AAD03694.1; JOINED; Genomic_DNA EMBL AF086946; AAD03694.1; JOINED; Genomic_DNA EMBL BT006758; AAP35404.1; -; mRNA CCDS CCDS1939.1; -. [Q14203-1]; . CCDS CCDS46341.1; -. [Q14203-4]; . CCDS CCDS46342.1; -. [Q14203-5]; . CCDS CCDS46343.1; -. [Q14203-2]; . CCDS CCDS54368.1; -. [Q14203-3]; . CCDS CCDS54369.1; -. [Q14203-6]; . RefSeq NP_001128512.1; NM_001135040.2. [Q14203-4]; . RefSeq NP_001128513.1; NM_001135041.2. [Q14203-5]; . RefSeq NP_001177765.1; NM_001190836.1. [Q14203-3]; . RefSeq NP_001177766.1; NM_001190837.1. [Q14203-6]; . RefSeq NP_004073.2; NM_004082.4. [Q14203-1]; . RefSeq NP_075408.1; NM_023019.3. [Q14203-2]; . UniGene Hs.516111; -; . PDB 1TXQ; X-ray; 1.80 A; A=15-107 PDB 2COY; NMR; -; A=1-99 PDB 2HKN; X-ray; 1.87 A; A/B=18-111 PDB 2HKQ; X-ray; 1.86 A; B=18-111 PDB 2HL3; X-ray; 2.03 A; A/B=18-111 PDB 2HL5; X-ray; 1.93 A; C/D=18-111 PDB 2HQH; X-ray; 1.80 A; A/B/C/D=15-107 PDB 3E2U; X-ray; 2.60 A; A/B/C/D=18-111 PDB 3TQ7; X-ray; 2.30 A; P/Q=27-97 PDBsum 1TXQ; -; . PDBsum 2COY; -; . PDBsum 2HKN; -; . PDBsum 2HKQ; -; . PDBsum 2HL3; -; . PDBsum 2HL5; -; . PDBsum 2HQH; -; . PDBsum 3E2U; -; . PDBsum 3TQ7; -; . ProteinModelPortal Q14203; -; . SMR Q14203; -; . BioGrid 108007; 236; . DIP DIP-31365N; -; . IntAct Q14203; 197; . MINT MINT-5004548; -; . STRING 9606.ENSP00000354791; -; . iPTMnet Q14203; -; . PhosphoSitePlus Q14203; -; . SwissPalm Q14203; -; . BioMuta DCTN1; -; . DMDM 17375490; -; . OGP Q14203; -; . EPD Q14203; -; . MaxQB Q14203; -; . PaxDb Q14203; -; . PeptideAtlas Q14203; -; . PRIDE Q14203; -; . DNASU 1639; -; . Ensembl ENST00000361874; ENSP00000354791; ENSG00000204843. [Q14203-1]; . Ensembl ENST00000394003; ENSP00000377571; ENSG00000204843. [Q14203-6]; . Ensembl ENST00000409240; ENSP00000386406; ENSG00000204843. [Q14203-3]; . Ensembl ENST00000409438; ENSP00000387270; ENSG00000204843. [Q14203-5]; . Ensembl ENST00000409567; ENSP00000386843; ENSG00000204843. [Q14203-4]; . Ensembl ENST00000633691; ENSP00000487724; ENSG00000204843. [Q14203-2]; . GeneID 1639; -; . KEGG hsa:1639; -; . UCSC uc002sku.4; human. [Q14203-1]; . CTD 1639; -; . DisGeNET 1639; -; . GeneCards DCTN1; -; . GeneReviews DCTN1; -; . H-InvDB HIX0204314; -; . HGNC HGNC:2711; DCTN1; . HPA CAB009108; -; . HPA HPA034635; -; . MalaCards DCTN1; -; . MIM 105400; phenotype; . MIM 168605; phenotype; . MIM 601143; gene; . MIM 607641; phenotype; . neXtProt NX_Q14203; -; . OpenTargets ENSG00000204843; -; . Orphanet 803; Amyotrophic lateral sclerosis; . Orphanet 139589; Distal hereditary motor neuropathy type 7; . Orphanet 178509; Perry syndrome; . PharmGKB PA27180; -; . eggNOG KOG0971; Eukaryota; . eggNOG COG5244; LUCA; . GeneTree ENSGT00760000119173; -; . HOGENOM HOG000015352; -; . HOVERGEN HBG004956; -; . InParanoid Q14203; -; . KO K04648; -; . OMA PEDSTMQ; -; . OrthoDB EOG091G0WO0; -; . PhylomeDB Q14203; -; . TreeFam TF105246; -; . Reactome R-HSA-2132295; MHC class II antigen presentation; . Reactome R-HSA-2565942; Regulation of PLK1 Activity at G2/M Transition; . Reactome R-HSA-380259; Loss of Nlp from mitotic centrosomes; . Reactome R-HSA-380270; Recruitment of mitotic centrosome proteins and complexes; . Reactome R-HSA-380284; Loss of proteins required for interphase microtubule organization from the centrosome; . Reactome R-HSA-381038; XBP1(S) activates chaperone genes; . Reactome R-HSA-5620912; Anchoring of the basal body to the plasma membrane; . Reactome R-HSA-6807878; COPI-mediated anterograde transport; . Reactome R-HSA-6811436; COPI-independent Golgi-to-ER retrograde traffic; . Reactome R-HSA-8854518; AURKA Activation by TPX2; . SIGNOR Q14203; -; . ChiTaRS DCTN1; human; . EvolutionaryTrace Q14203; -; . GeneWiki DCTN1; -; . GenomeRNAi 1639; -; . PMAP-CutDB Q14203; -; . PRO PR:Q14203; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000204843; -; . CleanEx HS_DCTN1; -; . ExpressionAtlas Q14203; baseline and differential; . Genevisible Q14203; HS; . GO GO:0015629; C:actin cytoskeleton; IDA:HPA; . GO GO:0031252; C:cell leading edge; IEA:Ensembl; . GO GO:0005814; C:centriole; IDA:UniProtKB; . GO GO:0005813; C:centrosome; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; TAS:ProtInc; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0005869; C:dynactin complex; IEA:InterPro; . GO GO:0030286; C:dynein complex; IEA:UniProtKB-KW; . GO GO:0000776; C:kinetochore; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005874; C:microtubule; IDA:UniProtKB; . GO GO:0035371; C:microtubule plus-end; IDA:UniProtKB; . GO GO:0005635; C:nuclear envelope; IDA:UniProtKB; . GO GO:0005819; C:spindle; IDA:UniProtKB; . GO GO:0000922; C:spindle pole; IDA:UniProtKB; . GO GO:0008017; F:microtubule binding; IDA:UniProtKB; . GO GO:0003774; F:motor activity; IEA:UniProtKB-KW; . GO GO:0015631; F:tubulin binding; IDA:UniProtKB; . GO GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome; . GO GO:0010457; P:centriole-centriole cohesion; IMP:UniProtKB; . GO GO:0097711; P:ciliary basal body docking; TAS:Reactome; . GO GO:0006888; P:ER to Golgi vesicle-mediated transport; TAS:Reactome; . GO GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome; . GO GO:0032402; P:melanosome transport; IEA:Ensembl; . GO GO:0034454; P:microtubule anchoring at centrosome; IMP:UniProtKB; . GO GO:0007067; P:mitotic nuclear division; NAS:ProtInc; . GO GO:0007399; P:nervous system development; NAS:UniProtKB; . GO GO:1905515; P:non-motile cilium assembly; IMP:UniProtKB; . GO GO:0051081; P:nuclear envelope disassembly; IMP:UniProtKB; . GO GO:0090063; P:positive regulation of microtubule nucleation; IDA:UniProtKB; . GO GO:0031116; P:positive regulation of microtubule polymerization; IDA:UniProtKB; . GO GO:0042147; P:retrograde transport; endosome to Golgi; IMP:UniProtKB GO GO:0010970; P:transport along microtubule; IEA:InterPro; . Gene3D 2.30.30.190; -; 1; . InterPro IPR000938; CAP-Gly_domain; . InterPro IPR027663; DCTN1; . InterPro IPR022157; Dynactin; . PANTHER PTHR18916:SF54; PTHR18916:SF54; 1; . Pfam PF01302; CAP_GLY; 1; . Pfam PF12455; Dynactin; 1; . SMART SM01052; CAP_GLY; 1; . SUPFAM SSF74924; SSF74924; 1; . PROSITE PS00845; CAP_GLY_1; 1; . PROSITE PS50245; CAP_GLY_2; 1; .

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